Grief

Graham O'Brien is haunted by the memory of his wife, Grace. (TV: Arachnids in the UK)

Grief was an emotion. Grief had five stages, ending in acceptance. The Shroud fed on grief, and exploited victims who had recently lost a loved one. (PROSE: Shroud of Sorrow)

According to Graham O'Brien, "[grief] needs time". He decided to continue travelling with the Thirteenth Doctor as a way of coping with his grief regarding the death of Grace, rather than wait for it to "go away", and let it consume him, in a house filled with the memories she had left behind. When he did visit their home, Graham's grief manifested in his mind in the image of Grace, who spoke to him. (TV: Arachnids in the UK)

In response to negative emotions such as fear, grief and anger, humans once took medication in the future, to remove and override them. (AUDIO: Harvest of the Sycorax) Some people used anti-depressants to help cope. (PROSE: Shroud of Sorrow)

When the Emojibots first encountered grief, they considered it an enemy of happiness and thought of destroying it, they called upon the Vardy to kill anyone who wasn't happy, stripping them of skin, organs and muscle leaving behind their skeleton, which later would be used to make calcium-based fertiliser. (TV: Smile)

The Seventh Doctor created the John Smith persona to help him understand the human emotion of grief that Bernice Summerfield was feeling after the death of Guy de Carnac. (PROSE: Human Nature) a man she loved, who sacrificed himself to save them. (PROSE: Sanctuary)