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A reproduction of the Orient Express was built that travelled in space. It attempted to recreate the land-based Orient Express down to the fine details, with some omissions. (TV: Mummy on the Orient Express)
The Eleventh Doctor received a call requesting his presence as it was having trouble with an "Egyptian Goddess" who had escaped from the Seventh Obelisk. (TV: The Big Bang)
Eventually the Twelfth Doctor heeded the request, confessing to Clara Oswald that he knew they were being lured into a trap. The Foretold, a mythical mummy, murdered several passengers. The Doctor explained it to be a soldier, waiting to be dismissed from his duties. When the Time Lord attempted to find out who had organised the gathering on the train, its computer, Gus blew up the vehicle. (TV: Mummy on the Orient Express)