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Newblood was an informal term for Time Lords of newer Houses. Newblood Time Lords were Loomed with a secondary heart from the outset. For them, a change of body was as trivial as a change of fashion. Newblood Time Lords never played Eighth Man Bound. (NA: Christmas on a Rational Planet)
At the auction for the Relic, the Shift wondered if the Eighth Doctor was representing one of the newblood Houses. (EDA: Alien Bodies)
Behind the scenes
Although the term implies there is such a thing as an "oldblood", the term is never used in DWU stories. "Oldblood"does make an appearance in FPU fiction, however.