Trenzalore was a place that, according to Dorium Maldovar, the Doctor would visit at some point in his travels, which would coincide with 'the Fall of the Eleventh'. Maldovar also told the Doctor that at this time and place 'no living creature can speak falsely or fail to answer.' Here, the First Question in the universe would be asked.
The Silence were determined that the Doctor never reach Trenzalore, so that the question would never be answered. It was a creed of the Silence that 'Silence will fall when the Question is asked', or as Maldovar translated it, 'Silence must fall'. (TV: The Wedding of River Song)
This is the place where all is revealed about The Doctor and Clara answering the questions who is the impossible girl? and the ultimate question doctor who?