The Ides Scientific Institute was set up at an unknown point before July 1970 and Doctor Sally Armstrong was working on the 'Voice Synthesizing Artificial Intelligence' (VSAI 0001) when Kotris posing as the Doctor gave the Institute one billion pounds sterling.
Sally then set up the Institute in 107 Baker Street under the instructions of Kotris posing as the Doctor and had the institute build a time-space portal. The Doctor later visited the Institute with Molly O'Sullivan and believed that he had set up the Institute some time in his future. While he was there Doctor Sally Armstrong activate the time-space portal. The Daleks came through the portal and chased them from the Institute. (AUDIO: Fugitives)
The Doctor, Molly and Liv Chenka took a trip to the Ides Institute later in the 1970s after noticing that the Ides Institute had sent out the Orpheus knowing that the Eminence would be at its destination. At this time the Reborn Master and Sally were working there. The Master used the Institute in his plan to experiment on the Eminence in order to pit them against the Daleks. (AUDIO: Eyes of the Master)