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A space plague was a type of disease.
The Daleks caused a space plague with "plague missiles". The only cure was parrinium. (TV: Death to the Daleks)
During the mid-21st century, the Doctor helped the Draconians with a space plague. (TV: Frontier in Space)
A space station threatened by a space plague was saved by disinfectodroids. However, their obsessive programming made them clean up everything, including the station occupants, and dumped them all on an alien planet. The Tenth Doctor and Rose Tyler were sent to the same planet when they arrived on the station. (COMIC: The Germ War)