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When Chloe Webber swallowed an Isolus, her drawings began to come to life.
When she scribbled out a drawing, the Scribble came to life. It hid in a garage, when Rose Tyler opened it, it lept out at her. The Doctor shone his Sonic screwdriver on the creature, it died and retracted into a small ball.
While examining it in the TARDIS, the Doctor discovered it was made from led, he demonstrated to Rose by erasing part of it with a pencil eraser. The Doctor and Rose then knew that drawings were mysteriously coming to life. (DW: Fear Her)