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Hamnet was, by 1599, the only son of William Shakespeare. He was taken by the Black Death while his father was away. His passing caused Shakespeare to question the futility of his own existence. (TV: The Shakespeare Code)
Shakespeare mentioned him, believing it was time he wrote a play about fathers and sons in his memory. Martha Jones questioned the name as Shakespeare would later go on to write a play called Hamlet. (TV: The Shakespeare Code, The Chase)