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The Twelve was the main alias used by the twelfth incarnation of a Renegade Time Lord who suffered from regenerative dissonance.
When Liv Chenka was trying to work out the identity of The Master, she initially thought he might have been The Twelve (AUDIO: Day of the Master)
At some point, the Eleven regenerated into a female body. The Twelve had a much better control of the incarnations within her mind, due to a neural inhibitor given to her by the Time Lords, although she also considered herself as possessing the firm hand necessary to keep them all in line even without the chip. She was assigned on a mission by the High Council to help the Eighth Doctor investigate the origins of an Ogron which declared itself to also be the Doctor.
During this time, she proved her control over her previous selves by summoning the Nine's personality when she and the Doctor needed to break into the Daleks' base. (AUDIO: Planet of the Ogrons)
She was captured by the Daleks, along with the Doctor and Bliss and taken to a facility with her memory suppressed. She was given the name "Pi Gamma" by Bliss. Without her neural inhibitor, she had to work harder to keep her other incarnations suppressed. She attempted to break out of the facility, with her previous incarnations prodding and goading her, forcing her to develop a means of disrupting the transmat technology using the cybernetic components of another prisoner. (AUDIO: In the Garden of Death)
After the encounter with the Daleks on Uzmal, Cardinal Ollistra had the Twelve put into stasis. (AUDIO: Jonah)