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Chen-7, also known as the One Day Plague, was a pathogen capable of killing individuals within the space of a single day. Only species with binary vascular systems, including Apalapucians and Time Lords, could contract the disease whilst one-hearted species such as humans were immune.
When a Chen-7 plague threatened the planet of Apalapucia, the Apalapucians created the Two Streams Facility, which used temporal technology to isolate the patients and stretch out the day into a lifetime. The Eleventh Doctor stated that he would be unable to regenerate if infected, and thus sent Rory into the Facility to locate Amy. (TV: The Girl Who Waited)