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Patient One was a patient at Hawthorne. His existence there was apparently secret. After Patient Zero's death and the thwarting of Dr Colin Dove's plan at perihelion, Peter Russell had a strange reaction to holding a knife and seemed to have a connection to Patient One, who laughed menacingly and sang "Daisy Bell" just as Zero and Russell had whilst possessed by the reservoir of evil. (HOMEVID: The Zero Imperative)
In 1997, Patient One escaped Hawthorne. Dr Haggard recaptured him and had him locked up in a secure facility at St Jude's. (PROSE: Preternatural Nights)