I think we need to go as simple as possible, there is just too much information on the main page at the moment.
There's also just a lot of DW related stuff produced month to month. Even when the TV series isn't on air there's a lot of audios, novels and comics being published/released.
The quotes don't do much harm, but they're another thing to keep updated and as Shambala108 says they're occasionally inaccurate. SirBanstead, we have in the past voted on quotes and articles and it's just a lot of work that not a huge amount of people participated in and really wasn't worth it. As quotes aren't something we focus on hugely I'd suggest we get rid of them.
For wikis that I think have the right idea for their main pages I'd suggest the Stargate Wiki, which has a fairly simple and clean layout.
I think that we should do something similar to the Stargate Wiki and have a gallery-slider that has the recently released/published stories One story from each medium. So we'd have 4 images that cycle a TV story, an audio story, a comic story and a prose story.
I think the random series links could stay. But everything else would be removed. So we'd replace the "latest" sections with the gallery slider. And probably keep the "article of the minute", "feature images" and "news" sections on the right. This should mean that the page would shrink in height to more than half it is currently.