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Gregorio was a human who was turned into a vampire around the 16th century.
Prior to becoming a vampire, he had been involved in Spanish conquest of the Aztec Empire, specifically recalling having visited Tenochtitlan.
By 1997 he had largely lost interest in conversation, although he still provided counsel to Joanna Harris.
Along with several other older vampires, he was killed by Slake via a stake to the heart, although he was able to survive long enough to warn Harris of Slake's plans. (PROSE: Vampire Science)