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The Time Spiral is a mysterious phenomenon located in the Time Vortex. The Time Spiral is located somewhere near the end of the Humanian Era, which is the probable reason why Time Lords can't go past that period in time.
This Time Spiral can rip apart a TARDIS and anyone inside if it comes too close. This is why each TARDIS has a device fitted that causes it to materialize anytime it comes too close to the Time Spiral. Unfortunately, The Doctor removed his at some point.
The Doctor, Romana and K-9 were nearly destroyed by the Time Spiral. (MA: The Well-Mannered War).