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The Sisterhood of Karn was a female society dedicated to protecting the Sacred Flame, which produced the Elixir of Life.
The Sisterhood was a remnant of the Pythia's power. (NA: Cat's Cradle: Time's Crucible)
The Sisterhood fought against Morbius when he attempted to invade Karn. (PDA: Warmonger)
When the Sacred Flame appeared to be dying, the Sisterhood suspected [[Fourth Doctor}the Doctor]] of trying to steal the remaining Elixir, but later helped him defeat Morbius. (DW: The Brain of Morbius)
After Romana became President of Gallifrey, she opened diplomatic relations with the Sisterhood. (NA: Lungbarrow)