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Doctor Renfrew was the director of a children's home in America which closed down. He remained in the home, unknowingly under the control of the Silence to care for a little girl they were interested in.
In 1969, he was visited by Amy Pond and Canton Delaware, who were searching for the girl. By this time he had been driven mad, still believing it to be 1967. He however tried to help the two visitors. (DW: Day of the Moon)