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Doctor Renfrew was the director of a children's home in America which closed down. He remained in the home, unknowingly under the control of the Silence to care for a little girl they were interested in.
In 1969, he was visited by Amy Pond and Canton Delaware, who were searching for the girl. By this time he had been driven mad, still believing it to be 1967. He however tried to help the two visitors, and was with Canton going through files when they were approached by a Silent, which the latter shot. After Canton went after hearing Amy scream, he followed to seek help. He found Canton, the Doctor and Rory Williams examining an astronaut suit, and led them to the Silent. (DW: Day of the Moon)