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Doctor Renfrew was the director of Graystark Hall, a children's home in America which had closed down. He remained in the home, unknowingly under the control of the Silence to care for a little girl they were interested in.
In 1969, he was visited by Amy Pond and Canton Delaware, who were searching for the girl. By this time he had been driven mad, still believing it to be before 1967. However, he tried to help the two visitors, and was examining files with Canton when they were approached by a Silent, which the latter shot. After Canton ran upstairs, hearing Amy's scream, Renfrew followed to help. He found Canton, the Doctor and Rory Williams examining an astronaut suit, and led them to the Silent. (DW: Day of the Moon)