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House was a malevolent mysterious entity that was native to a smaller bubble universe that was outside that occupied by the main universe. It existed as an intelligence that resided in a time rift where its body was that of an asteroid sized body.
The creature gorged itself on artron energy and at some point discovered the existence of the Time Lords whose TARDIS's were filled with such a power source. Thus, it began the practice of using Gallifreyan distress signals to lure Time Lords to its surface where they were trapped. Once there, House deleted the TARDIS's Matrix whereupon it devoured the TARDIS to feed itself. The trapped Time Lord were left behind where they eventually would perish. House's encounters with the Time Lords led it to calling them a kind race.
During its existence, Uncle, Auntie, the Ood Nephew and Idris came upon House where they lived on its surface. As Time Lords died on the surface of House, he used his powers to renew the bodies of his servants and replaced their dying bodies from those taken from the dead Gallifreyans. Thus, they became an extension of his will and did his tasks. In 2011, House grew hungry once more and once more conducted the practice of attempting to entrap a Time Lord thus attracting the attention of the Eleventh Doctor who was accompanied by Amy Pond and Rory Williams.
Upon their arrival, House used his influence to remove the Doctor's TARDIS's Matrix thus leaving it blank in order for it to be consumed. However, during a conversation with the Doctor, House learnt that the Time Lords had perished in a terrible conflict. Seeing that its food source had been eliminated, House decided to change its pattern of behaviour by possessing the now empty TARDIS and attempted to use it to reach the mainstream universe in order to find new sources of energy. To amuse itself, it used the TARDIS's body to play with the lives of Amy and Rory. However, the Doctor had managed to construct a partial TARDIS from the remains of the time ships left on House's home. The Doctor's TARDIS Matrix was eventually released from her dying Human body allowing it to repossess her time ship whereupon House's essence was expunged from the ship.