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The 4th century was a time of great change for Christianity. After centuries of squabbling over the canonicity of the Bible, leaders of the Christian Church from all over the the Middle East, Africa and Europe met at the Council of Nicaea to finally settle how the text of the Bible should read. The Fifth Doctor, Peri and Erimem were on hand at the conference, held in 325. (BFA: The Council of Nicaea) Also, the Second Doctor likely befriended Saint Nicholas in the early part of the century, (ST: Saint Nicholas's Bones) and the Eighth Doctor and Charley stopped a Nimon invasion. (BFA: Seasons of Fear)
As was true of the first 21 AD centuries, in a timeline which may have been invalidated by Big Bang Two, the Pandorica continued to house an ailing Amy Pond, and to be guarded by an Auton duplicate of her fiancé. (DW: The Big Bang)