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San Francisco was a city located in California in the United States of America.
On 18th April 1906, San Francisco was ravaged by an earthquake and consumed by fire. Azathoth and her rakshassi army, having been diverted here by the Doctor, were consumed in the fire. (NA: All-Consuming Fire) The vampire known as Weird Harold was found buried alive after the earthquake. (EDA: Vampire Science)
In 1967, when the city was the hub of the hippie movement, the Second Doctor, Ben Jackson and Polly Wright visited and battled the Goblin. (TN: Wonderland)
In 1976, the Eighth Doctor and Sam Jones visited San Francisco and saved Carolyn McConnell from a vampire. They then travelled to 1997 to battle more vampires. (EDA: Vampire Science)
On New Year's Eve 1999, San Francisco was the site of the Doctor's regeneration into his eighth incarnation. (DW: Doctor Who) On Christmas Day, year 2000 an unknown incident occurred in San Francisco.
The Doctor attempted to save Chang Lee from this event by telling him, on New Year's Day, to take a Christmas holiday. (DW: Doctor Who)
In November 2002, the Doctor, Sam and Fitz Kreiner visited San Francisco. Sam and the TARDIS fell into a dimensional anomaly. Sam was reverted to her original timeline, but sacrificed herself to save the TARDIS and San Francisco. (EDA: Unnatural History)
Around 2011, San Francisco fell into the sea. (EDA: The Janus Conjunction) However, a city named San Francisco was around in the 22nd century (EDA: The Face-Eater) and the 26th century. (BNA: Beige Planet Mars)