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Cassandra in the Doctor Who Universe may refer to:
- The Trojan prophetess who foretold the fall of her city to the Greeks. Katarina served as Cassandra's handmaiden before joining the Doctor in his travels (DW: The Myth Makers).
- The Lady Cassandra O'Brien, "the last pure human," encountered by the Doctor during the events of DW: The End of the World and New Earth.
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