The Isari were a species who were active in the Mutters Spiral by 3000 BC. They were engaged in a protracted, destructive conflict with the Anar, which lasted for over two thousand years. In 3000 BC, the planet Iytea was "nearly destroyed" in the wars' crossfire, wiping out most of the Iyteans. (GAME: The Iytean Menace [+]Loading...["The Iytean Menace (game)"]) In the Infinity Doctor's reality, General Sontar was renowned as "the mastermind behind the victory in the two‐thousand‐year war with the Isari". (PROSE: The Infinity Doctors)
During the Ghost Wars, the vampire Garglespike owned a copy of the Isari Revised Dictionary 1978, a technologically-advanced dictionary containing definitions for multiple languages, including English, and a built-in translation matrix. When she wasn't using it, she shrank it down into a book-shaped pin on her lapel using acumancy. (PROSE: The Bloodletters)