The offspring or children of an individual were their immediate descendants. (TV: The Dalek Invasion of Earth, The Stolen Earth) They were separable into sons and daughters. (TV: An Unearthly Child et al.)
On Jaconda, a legend told that the Sun God was offended by the queen of the planet, so it sent its offspring, the Gastropods to devastate it in retribution. (TV: The Twin Dilemma)
The 456 ambassador used the term, along with descendant, to clarify his order to John Frobisher for 10% of the Earth's children. (TV: Children of Earth: Day Three)
The Eleventh Doctor observed that only the male offspring of Rosanna Calvierri survived the journey from Saturnyne to Earth, forcing her to convert human females into Saturnyns. (TV: The Vampires of Venice)
When the First Doctor met the Ashtallans, he helped Brenna and Sharlan create an offspring via cloning. (AUDIO: The Invention of Death)