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Pilot's Heart was a disease common among Neuro Pilots in the 67th century. It primarily caused heart failure when under stress, due to adrenaline building up around the heart, hence its name. The only way to prevent such was constant injections of adrenaline blockers, though one had to increase how many they took the longer they had the disease.
Eve Cicero suffered from it and this embarrassed her, so she hid it to protect her reputation. Eve ultimately succumbed to this disease while flying the Tsuranga to Resus One. (TV: The Tsuranga Conundrum)