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- Isaac (A Town Called Mercy)
- Isaac (Believe)
- Isaac (Bunker Soldiers)
- Isaac (disambiguation)
- Isaac Asimov
- Isaac Barclay
- Isaac Chee
- Isaac Dobbs
- Isaac Greatorex
- Isaac Greatorex's cult
- Isaac Newton
- Isaac Pawley
- Isaac Penley
- Isaac Smith
- Isaac Stephen Montgomery
- Isaac Summerfield I
- Isaac Summerfield II
- Isaac Summerfield II/Appearances