Gout

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Gout was a disease. The wife of Kublai Khan disapproved of him gambling at backgammon in 1289 as she believed it aggravated his gout. (TV: "Assassin at Peking")

According to Charles, his father conveniently felt the effects of a draft or his gout when he was losing at a game in 1666. (TV: The Visitation)