The First
From Tardis Wiki, the free Doctor Who reference
The First was the first ever creature of the universe. She saw herself as the mother of all living things. She slept for thousands of years, waking to find her children fighting, causing wars and sadness. This caused her to create a Reality Virus, to wipe out all creation and start again.
The Thirteenth Doctor and the Player stopped her by sealing her in a timeloop. (GAME: The Edge of Time)