Staser

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Staser gun pointing Lord President Of Gallifrey(DW: The Deadly Assassin)

Staser weapons were the standard armament of the Chancellory Guard on Gallifrey. The Guards were normally equipped with staser pistols, although staser rifles were also occasionally used.

Stasers had both lethal and non-lethal settings. They were relatively non-damaging to inorganic matter but caused massive tissue disruption to living creatures. (DW: The Deadly Assassin)

As a result a single staser shot could apparently kill a Time Lord outright and ensure that regeneration could not take place.