Operating system
When trying to find out about the people controlling the Spoonheads, the Eleventh Doctor successfully hacked the lowest level of their operating system, but couldn't establish a physical location. (TV: The Bells of Saint John [+]Loading...["The Bells of Saint John (TV story)"])
Very early versions of the Cyber operating system could be "seriously scrambled" by exposure to gold or cleaning fluid. "Mr Clever" was still running some of that code when it encountered the Eleventh Doctor. (TV: Nightmare in Silver [+]Loading...["Nightmare in Silver (TV story)"])
The Moment was a weapon so powerful its operating system became sentient. (TV: The Day of the Doctor [+]Loading...["The Day of the Doctor (TV story)"])