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The International Space Station, or ISS, orbited Earth in the early 21st century. It was located 400 kilometres above the surface of the planet.
Canadian Chris Hadfield made a video of himself singing on the ISS, creating public interest in space exploration.
In 2015, the crew included Russian Dimitri Yemtov, South Korean Lee Jae-Yong, Cory, and Quinn led by Major Weir. That year, the ISS was destroyed by a Hyperion falling to Earth, killing the entire crew. (COMIC: The Hyperion Empire)
While rotating around the Earth in search of a puncture in time, the Ninth Doctor, accompanied by Rose Tyler, had to fly the TARDIS fast enough to avoid detection by the International Space Station. (PROSE: Rose and the Snow Window)
In the 2050s, the Tenth Doctor and Donna Noble visited the International Space Station, which was invaded by Mange Mites. (COMIC: Attack of the Mange Mites!)