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As spoken by the Fourth Doctor, C (Morse code: -.-. (TV: The Man Who Never Was)) was the third letter of the alphabet, following B and preceeding D. (TV: The Masque of Mandragora)
The Cybermen of Pete's World had the letter C engraved on their chests to represent the company that created them, Cybus Industries. (TV: Rise of the Cybermen)
As early as his sixth incarnation, the Doctor kept a "C chest" aboard his TARDIS, named for containing a cache of items marked by the letter C. (AUDIO: The Carrionite Curse, TV: The Unicorn and the Wasp)
In November 1963, science teacher Ian Chesterton set his Coal Hill School class a problem with the letters A, B and C representing the three dimensions. However, Susan Foreman pointed out that he had not acknowledged two additional dimensions: D, which Ian reasoned was time, and E, which Susan revealed was space. (TV: An Unearthly Child)
Cathica Santini Khadeni clarified that her name was "Cathica with a C". (TV: The Long Game)