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Humanity's first great break-out (PROSE: The Romance of Crime) occurred in the early 23rd century, following the 22nd century Dalek invasion of Earth which itself followed the initial Break-out of the late 21st century. (PROSE: Prelude Deceit)
In 2230, during the early years of the "first great break-out", humans colonised the Uva Beta Uva system located near the center of the galaxy. There, they settled on Uva Beta Uva Five, renaming it New Earth. (PROSE: The Romance of Crime)
A much larger Break-out, the Great Breakout, occurred in 5000. (TV: The Invisible Enemy) The Ninth Doctor told Rose Tyler that, by the 51st century, humanity would have spread out across "half the galaxy". (TV: The Doctor Dances) The dispersal of humanity allowed the evolving species to survive the natural destruction of their homeworld in the year 5,000,000,000, (TV: The End of the World) after which they made their home on a planet in galaxy M87 which they also named New Earth. (TV: New Earth)