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Alpha Meson was a type of energy.
It was used as "alpha meson phosphor", the presence of which could provide a light source throughout a building without the need for bulbs or openings to natural light. (TV: The Tomb of the Cybermen)
River Song carried an Alpha Meson blaster, capable of disintegrating a wooden cabinet (TV: The Pandorica Opens) and destroying a weakened Dalek. (TV: The Big Bang)
Behind the scenes
In The Tomb of the Cybermen, the energy was pronounced as "May-zon", while in The Big Bang, it was pronounced as "Mee-zon".