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Novice Hame was a member of the Sisters of Plenitude residing on the planet New Earth. She was arrested by the New New York Police Department She was at that time looking after the Face of Boe in Ward 26 of the New New York hospital when, with others of her religious order, she was arrested by the New New York Police Department, as conspirators in secretly breeding "the Flesh", cloned humans infected with all known diseases in to research cures. (DW: New Earth)
Subsequently, Novice Hame was ordered to look after the Face of Boe as a punishment for her sins she committed when she was one of the Sisters of Plenitude.
When the airborne Bliss virus killed the New New York Senate and most of the New Earth population, Hame, who had been saved from the virus by the Face of Boe, smoke from whose tank shielded and protected her. She aided the Face in sealing off the Undercity of New New York, thereby saving those on the Motorway and in the streets there.
When the Doctor returned, thirty years after he arrest, Hame was sent to look for him by the Face. She found him deep in the Motorway whilst he was looking for Martha Jones and teleported him to the New New York Senate so that the Face of Boe could deliver his final message. Hame was with them as he died, imparting his final words to the Doctor. The Doctor felt convinced that Hame had actually reformed and stated to his companion Martha Jones that "they'll have Novice Hame" assuming she will now have a larger role in the governance of New New York and/or the planet of New Earth itself. (DW: Gridlock)