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Demon's Run was an asteroid where Amy Pond was held prisoner by Madame Kovarian and her associates, the Anglican Regiment of the Church.
On this asteroid, Amy gave birth to her daughter Melody (or as she would later be known, River Song). The Eleventh Doctor, Rory Williams, and a force of allies stormed Demon's Run and rescued Amy, but Kovarian escaped with Melody. Melody's future self, River Song, appeared after the battle to reveal her true identity. The Doctor then departed the asteroid alone, to find the infant Melody.
There is a saying that goes with Demon's Run: "Demons Run, when a good man goes to war." (DW: A Good Man Goes to War)