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The Second Great and Bountiful Human Empire has, by this time, spread throughout three galaxies. (DW: Planet of the Ood) A destructive war with the Daleks breaks out. (BFDE: Dalek Empire)
Major Events
- 4126 - thanks to the Tenth Doctor and Donna Noble, the Ood become free across the Empire and are sent back to the Ood Sphere. (DW: Planet of the Ood)
- 4162 - the Dalek Empire of the Seriphia Galaxy invades Mutter's spiral. (BFDE: Invasion of the Daleks)
- Unknown - all Dalek technology is destroyed, causing the Great Catastrophe and collapse of galactic civilisation.
Minor Events
- The cargo ship S.S. Pentallian begins a fuel run on the sentient star, Torajii. Some of her crew are possessed by the intelligence and the S.S. Pentallian is drawn towards the sun. (DW: 42)
- 43K2.1: Sanctuary Base 6 is assaulted by the Beast and most of its crew are killed, but the Beast is defeated by the Doctor and Rose Tyler. (DW: The Impossible Planet, The Satan Pit)
- The Doctor asks Kalendorf for advice whether or not to help the Time Lords fight in the Last Great Time War. (ST: The End)