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A Human-Time Lord Meta-Crisis was the term applied to a hybridised organism that combined the traits of a Time Lord and human.
Only two have been known to exist - the "DoctorDonna" and the Meta-Crisis Doctor.
The DoctorDonna was an example of a human with a human brain and a Time Lord consciousness. She had to be reverted to her human self; her brain could not hold a such a consciousness. The Doctor had to erase her mind of all knowledge of him. (DW: Journey's End) Despite this, Donna's latent consciousness remained half-Time Lord, protecting her when the Master turned the world into copies of himself. Apparently, it also subconsciously guided her to buy a book for her grandfather, which led the Doctor and him to Joshua Naismith. (DW: The End of Time)
The Meta-Crisis Doctor seemed to be a mixture of the two races. He did not burn up, presumably having a Time Lord brain, but only had one heart and could not regenerate. He also showed quirks of Donna Noble, the human with whom the Meta-Crisis occurred. (DW: Journey's End)