The Isley Brothers was band made up of O'Kelly, Ronald and Rudolph Isley. (PROSE: Happy Endings) Their "best" song, according to the Seventh Doctor, was "This Old Heart of Mine". (AUDIO: Love and War)
When Teal Green was surprised to see Bernice Summerfield, she asked if he was "expecting the Isley Brothers". (PROSE: Lucifer Rising) The android Isley was named after this group, as it was her creator Albert Gilroy's favourite band. He often played their music while he was working. (PROSE: Nuclear Time)
They showed up at the wedding of Jason Kane and Professor Bernice Summerfield on 24 April 2010 - much to their own surprise. They led the singing of "Oh Little Town of Bethlehem". (PROSE: Happy Endings)