Broken generation
Mutations appeared in the breeding-engines and produced a broken generation of members of the Great Houses roughly 1200 years before the War in Heaven. (PROSE: The Book of the War)
The mutations particularly affected House Lungbarrow and House Dvora. Their causes remained "vague" but could be attributed to "impurities in the looming system". (PROSE: Crimes Against History)
Members of the broken generation included the Imperator, Grandfather Paradox, and the War King. (PROSE: The Book of the War) They were considered by later generations to be the original renegades. (PROSE: Crimes Against History)
The Doctor, the Master, the Rani, the Monk, and Drax were the same age and attended the Academy together, where they called themselves the Deca. (PROSE: The Quantum Archangel)