Kovarian
"Eye patch lady" was a mysterious woman, discovered by Amy Pond, who appeared at the little girl's bedroom door at Graystark Hall Children's Home. She wore an eyepatch or a similar device over her right eye. She appeared through a hatch in the door which later on disappeared. Amy was startled by the woman and asked who she was, but the woman ignored her and replied, "No, I think she's just dreaming," to someone inside the room. When Amy entered, the room appeared to be empty, with no evidence of the woman or the hatch. (DW: Day of the Moon)
While Amy is asleep on the pirate ship, she is woken, and a hatch opens, similar to the one in the Little Girl's bedroom door, in the side of the hull to reveal the woman. (DW: The Curse of the Black Spot)
I just looked at a picture of her in the door and if you look closley she looks like river song!