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Duke of Guise was a French title held by the Catholic Francois de Guise in the 16th century. On 1 March 1562, twenty-five Huguenots were killed at a Reform Church in Wassy, France by Francois de Guise. This act sparked the French Religious Wars. (TV: The Massacre [+]Loading...["The Massacre (TV story)"]; PROSE: The Massacre [+]Loading...["The Massacre"])