Fixed point in time

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The Doctor appearing to die at Lake Silencio, on 22 April 2011, was a notable fixed point in time. (DW: The Wedding of River Song)

Fixed points in time were moments in the space-time continuum at which events were set in stone. Time Lords could sense them at all times, which was maddening according to the Ninth Doctor. (DW: The Parting of the Ways) This was called 'the curse of the Time Lords' by the Tenth Doctor. (DW: The Fires of Pompeii)

Definition

Fixed points were events and/or individuals who had such long-standing impacts on the timeline that no one, not even Time Lords, dared interfere with their natural progression. The Doctor, free to interfere in alien invasions and save planets in most cases, could neither interfere nor interact with these fixed points. Were a fixed point to be interfered with, the change would be circumvented, making the timeline continue despite changes. (DW: The Waters of Mars) In other situations, time would freeze and collapse and reality would "die". With a "still point in time", such as Lake Silencio, it was easier to create a fixed point in time. (DW: The Wedding of River Song)

Notable fixed points

Implied to be a fixed point was the death of Pete Tyler on 7 November 1987. Rose Tyler saved his life, and the paradox allowed the invasion of the Reapers. The timeline returned to normal, with the Reapers gone, when Pete realised what had happened and ran out in front of the car that should have killed him, with the only thing changed in the new timeline being the place he died, and the fact that someone (Rose) was with him when he died. (DW: Father's Day)

The destruction of Ockora in 2204 was a fixed point. When the Second Doctor warned the Selachian Supreme Leader, he realised they would have been able to do something about it. The Supreme Leader and forty Selachian soldiers escaped the planet's destruction and got on-board the Triumph, the ship which dropped the G-bomb which destroyed Ockora. They killed everyone on the ship, but the other G-bomb was accidentally set off, leading to the formation of another black hole. The Doctor considered the formation of another black hole an acceptably small change. (PDA: The Final Sanction)

Jack Harkness became a fixed point in time after his resurrection by Rose Tyler, which caused him to become immortal. (DW: The Parting of the Ways, Utopia) Jack temporarily lost his immortality due to Miracle Day, but both he and Rex Matheson became immortal afterwards. (TW: The New World, The Blood Line)

Whether they both became fixed points is unknown.

The destruction of Pompeii by the Vesuvius volcano was a fixed point in time caused by the Doctor. As well as its eruption, the deaths of most of the citizens of Pompeii were fixed. The Doctor did save one family, despite his unwillingness to interfere further. (DW: The Fires of Pompeii)

The death of explorer Adelaide Brooke was one of the few times the Doctor intentionally interfered with a fixed point. His rationale was that, as the last surviving Time Lord, the Laws of Time were his to command. In the end, Brooke committed suicide, allowing the timeline to unfold with only minor changes. (DW: The Waters of Mars)

The Doctor also interfered with a fixed point in time a short while before or after the previous event, by saving the life of Emily Winter, a film actress in 1920s-era Hollywood. He was put on trial by the Shadow Proclamation for this. (IDW: Fugitive)

The Doctor appearing to die, in his eleventh incarnation, was a fixed point in time arranged by The Silence; the Doctor was seemingly killed in Utah, at Lake Silencio, on 22 April 2011 at 5:02 pm. When River Song tried to prevent this, an alternate timeline was created where all of time occurred at the same time and it was always 22 April 2011, at 5:02 pm. The Doctor set things right by kissing River, shorting out the time differential between them and making events revert to the moment when she was supposed to kill him, which she did. It was later shown that the fixed point was actually not his death, and the Doctor who had "died" was actually the Teselecta. (DW: The Impossible Astronaut, The Wedding of River Song)

Time in flux

The opposite of fixed points was time in flux. At these points time could change completely.

Flux points were relatively insignificant (on a universal scale) events that could be altered with relatively litlle to no consequence. The Doctor often meddled at these moments. (DW: The Christmas Invasion, QR: I am a Dalek) When the Tenth Doctor first met Martha Jones, he told her that "Crossing into established events is strictly forbidden ... except for cheap tricks." (DW: Smith and Jones)

Fluxing points